How do proton pump inhibitors work? Upper gastrointestinal tract and acid They have made a big impact on the quality of life of many people with these conditions since they first became available in the 1980s. PPIs usually work very well to reduce stomach acid and to treat the above conditions. In other conditions where it is helpful to reduce acid in the stomach.In a rare condition called Zollinger-Ellison syndrome.To help prevent and treat ulcers associated with anti-inflammatory medicines called non-steroidal anti-inflammatory drugs (NSAIDs).As one part of treatment to get rid of Helicobacter pylori - a germ (bacterium) found in the stomach, which can cause ulcers. These conditions are sometimes called gastro-oesophageal reflux disease (GORD). To reduce acid reflux which may cause heartburn or inflammation of the gullet (oesophagitis).To treat ulcers in the stomach and the part of the gut called the duodenum.What conditions are proton pump inhibitors used to treat?
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